Medication (Drug) Allergy

Medication or drug allergies, including to penicillin and other antibiotics, are more common in older age groups.

A medication or drug allergy occurs when the body’s immune system reacts to an administered medication.

Unlike side effects, which are common and often expected reactions to a medication, allergies involve an immune response that can range from mild to severe.

What types of drug allergies are there?

Broadly speaking, there are two types of drug allergy; immediate and non-immediate.  These can range in severity from mild through to severe.

  • Immediate type drug allergy: typically occur one-to-six hours after exposure. Symptoms can include vomiting, hives, and/or swelling of lips, face or eyes.
  • Non-immediate type drug allergy: occurs more than 24-hours after receiving a medication and encompasses a variety of different conditions, including maculopapular exanthem, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) and Steven-Johnsons syndrome / toxic epidermal necrolysis.

What drugs commonly cause medication (drug) allergy?

While any medication has the potential to cause an allergic reaction, some medications are more commonly associated with allergies. These include:

  • Antibiotics
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., aspirin, ibuprofen)
  • Some chemotherapy drugs
  • Biologic therapies
  • Anticonvulsants

Frequently Asked Questions

Immediate type drug allergy often present with following symptoms:

  • Hives
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or wheezing
  • Nausea, vomiting
  • Anaphylaxis (a severe, life-threatening reaction characterized by difficulty breathing and/or drop in blood pressure and/or loss of consciousness)

Non-immediate type drug allergy typically presents with skin symptoms, but can present with fever and systemic symptoms if severe.

While any medication has the potential to cause an allergic reaction, some medications are more commonly associated with allergies. These include:

  • Antibiotics
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., aspirin, ibuprofen)
  • Some chemotherapy drugs
  • Biologic therapies
  • Anticonvulsants

Diagnosis typically involves a combination of medical history, physical examination, and may involve allergy testing, such as skin prick tests or blood tests.

It is important to differentiate a drug allergy from an adverse reactions to a medication. For example, nausea with antibiotic use is a common adverse reaction, but is not a food allergy.

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